This virtual workshop will be led by the National Institute of Environmental Health Sciences (NIEHS) and the National Heart, Lung, and Blood Institute (NHLBI). It will bring together basic scientists, pediatricians, primary care physicians, maternal–fetal medicine experts, neonatologists, pulmonologists, cardiologists, nurses, pharmacists, epidemiologists, environmentalists, toxicologists, implementation scientists, data scientists, and community representatives to discuss the role of exposures to micro-nanoplastics (MNPs) and forever chemicals (perfluoroalkyl and polyfluoroalkyl substances ) across the lifespan in heart, lung, and blood disorders to identify critical research gaps, challenges, and opportunities.